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KMID : 0942820090080020143
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Journal of Korean Brain Tumor Society
2009 Volume.8 No. 2 p.143 ~ p.148
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Intratumoral Bleomycin Injection for Cystic Cranipharyngioma-Preliminary Report of Single Institution-
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Jang Woo-Young
Yang Seung-Ho
Hong Jae-Taek
Sung Jae-Hoon
Son Byung-Chul
Lee Sang-Won
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Abstract
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Objective: While total resection is a desirable goal for the treatment of craniopharyngioma, it is not always accomplished, and is associated with permanent endocrinological and visual deficits. This knowledge has led us to perform intratumoral bleomycin injection as a primary therapy for cystic craniopharyngioma.
Methods: Six patients(4 adult and 2 children) in whom cystic craniopharyngioma was diagnosed were treated primarily with a schedule of 3 mg of intracystic bleomycin administration, three times a week for 5 weeks. One patient was excluded due to bleomycin leakage in reservoir permeability test. Two out of remainders underwent subsequent resection and radiotherapy, and one was treated with ventriculoperitoneal shunt. Median follow-up period was 36 months.
Results: There was a reduction(>90%) in cyst size in 5 patients with the preservation of endocrinological function. However, the median recurrence-free survival was only 22 months.
Conclusion: Intracystic bleomycin administration could be a feasible option for the treatment of predominantly cystic craniopharyngioma in terms of symptom relief and pituitary function preservation. However, it is suggested that the efficacy of intraumoral bleomycin therapy is temporary and it has the risk of meningitis and neuropathy.
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KEYWORD
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Craniopharyngioma, Bleomycin, Intracystic therapy, Complication
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